DSIP
Neuropeptide discovered in 1977 that modulates delta sleep (deep slow-wave sleep). Researched for insomnia, stress management, and circadian rhythm regulation. Found naturally in the human brain.
Last updated:: 06/04/2026
Research Status
ANVISA (Brazil)
Not regulated
FDA (USA)
Not regulated
EMA (Europe)
Not regulated
Mechanism of Action
DSIP is a nonapeptide (9 amino acids) that modulates GABAergic and serotonergic activity in the brainstem and hypothalamus. It promotes slow-wave sleep (delta sleep), reduces cortisol levels, and modulates growth hormone release during sleep. It also influences LH production and the hypothalamic-pituitary-adrenal axis.
Study Protocols
Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.
Regulação do sono
Subcutânea (SC) ou IntranasalDelta Sleep-Inducing Peptide. Melhora latência e qualidade do sono em insones crônicos. Não causa dependência.
Benefits
Improved deep sleep
Under researchSmall clinical studies demonstrate increased slow-wave sleep and subjective improvement in sleep quality in patients with insomnia.
Stress reduction
Under researchStudies show reduced cortisol levels and normalization of the stress response in animal models and small human studies.
Risks and Side Effects
Limited clinical studies
Moderate(N/A)Clinical studies are outdated (1980s-1990s), small, and with questionable methodology by current standards.
Very short half-life
Low(N/A)Rapidly degraded in the blood (half-life ~7-8 minutes), questioning the efficacy of peripheral administration.
Internet vs. Science
What people say online compared to the actual scientific evidence.
Cures insomnia naturally
InconclusiveWhat they claim
DSIP is the natural sleep peptide — take it and sleep like a baby, without sleeping pill effects.
Actual evidence
Modulates deep sleep in some studies, but the evidence is weak and outdated. Extremely short half-life raises questions about whether it reaches the brain in effective quantities. Not a substitute for sleep hygiene or medical treatment of insomnia.
| Claim | O que dizem | Evidência real | Verdict |
|---|---|---|---|
| Cures insomnia naturally | DSIP is the natural sleep peptide — take it and sleep like a baby, without sleeping pill effects. | Modulates deep sleep in some studies, but the evidence is weak and outdated. Extremely short half-life raises questions about whether it reaches the brain in effective quantities. Not a substitute for sleep hygiene or medical treatment of insomnia. | Inconclusive |
Important notice
This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.
How to Obtain
This compound can be prepared by licensed compounding pharmacies with a valid prescription. Consult a physician first.