Fisetina
IMPORTANT: Fisetin is not a peptide; it is a flavonoid (polyphenol) found in fruits and vegetables such as strawberries (the richest source), apples, persimmons, grapes, and onions. It gained prominence in longevity research as a senolytic — a compound that selectively eliminates senescent ('zombie') cells that accumulate with age and contribute to chronic inflammation.
Last updated:: 07/04/2026
Research Status
ANVISA (Brazil)
Not regulated
FDA (USA)
Not regulated
EMA (Europe)
Not regulated
Mechanism of Action
Fisetin is classified as a senolytic — it induces selective apoptosis in senescent cells (old cells that stopped dividing but do not die, secreting inflammatory molecules). It also has antioxidant, anti-inflammatory, and neuroprotective properties. It crosses the blood-brain barrier.
Study Protocols
Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.
Senolítico / longevidade
OralProtocolo senolítico pulsado
Flavonoide senolítico. Em camundongos, estendeu expectativa de vida em 10%. Ensaio clínico AFFIRM em andamento na Mayo Clinic.
Benefits
Senolytic activity
Under researchDemonstrated in in vitro studies and in mice. It was identified as the most potent senolytic among flavonoids tested.
View studyIncreased lifespan in mice
Under researchMice treated with fisetin late in life had a 10% increase in lifespan and reduced senescence markers.
Neuroprotection
Under researchStudies in animal models of Alzheimer's and Parkinson's show neuroprotective effects and cognitive improvement.
Risks and Side Effects
Very low bioavailability
Moderate(Universal)Fisetin has very low oral absorption. Supplemental doses need to be much higher than those obtained naturally from the diet.
No completed human studies
Moderate(N/A)Human clinical trials are in phase 1/2 (e.g., Mayo Clinic study). Efficacy in humans has not yet been confirmed.
Internet vs. Science
What people say online compared to the actual scientific evidence.
Kills zombie cells and rejuvenates you
Partially trueWhat they claim
Fisetin is the natural senolytic that clears old cells and reverses aging.
Actual evidence
Senolytic activity is real in the lab and in mice. But the 'rejuvenating' effect in humans has not yet been demonstrated in clinical trials. Promising research, but not conclusive.
| Claim | O que dizem | Evidência real | Verdict |
|---|---|---|---|
| Kills zombie cells and rejuvenates you | Fisetin is the natural senolytic that clears old cells and reverses aging. | Senolytic activity is real in the lab and in mice. But the 'rejuvenating' effect in humans has not yet been demonstrated in clinical trials. Promising research, but not conclusive. | Partially true |
Studies and References (1)
Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. — EBioMedicine (2018)
Fisetina foi identificada como o flavonoide senolítico mais potente. Em camundongos idosos, restaurou homeostase tecidual, reduziu patologias relacionadas à idade e estendeu mediana de tempo de vida.
PubMedImportant notice
This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.
Where to Buy
This compound is available as a supplement. Purchase from trusted retailers:
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