Hormônio de Crescimento

Ipamorelin

Growth hormone secretagogue peptide that stimulates GH release from the pituitary gland. Considered one of the most selective secretagogues, with fewer side effects than others in the same class. Frequently combined with CJC-1295.

Last updated:: 06/04/2026

Research Status

Pré-clínicoFase 1Fase 2Fase 3Aprovado

ANVISA (Brazil)

Not regulated

FDA (USA)

Compounding only

EMA (Europe)

Not regulated

Mechanism of Action

Ipamorelin is a pentapeptide that acts as a ghrelin receptor (GHSR) agonist in the anterior pituitary, stimulating pulsatile growth hormone release. Unlike other secretagogues, it does not significantly affect cortisol or prolactin levels, making it more selective.

Study Protocols

Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.

Estímulo de GH / composição corporal

Subcutânea (SC)

Protocolo padrão200–300 mcg1–3x/dia · 8–12 semanas

Idealmente em jejum ou antes de dormir

GHRP seletivo, não eleva cortisol nem prolactina significativamente. Frequentemente combinado com CJC-1295.

Raun K et al., European Journal of Endocrinology 1998

Benefits

GH increase

Proven

Clinical studies confirm a dose-dependent increase in growth hormone release in healthy humans.

View study

Selectivity (fewer side effects)

Under research

Does not significantly raise cortisol or prolactin, unlike other secretagogues such as GHRP-6.

Risks and Side Effects

Headache

Low(Common)

Side effect frequently reported in clinical studies.

Water retention

Low(Variable)

Mild swelling may occur due to increased GH.

Internet vs. Science

What people say online compared to the actual scientific evidence.

Replaces HGH injections

Partially true

What they claim

Promoted as a safer and cheaper alternative to synthetic growth hormone.

Actual evidence

Stimulates natural GH release, but the levels achieved are significantly lower than with exogenous HGH. It is not equivalent.

Claim	O que dizem	Evidência real	Verdict
Replaces HGH injections	Promoted as a safer and cheaper alternative to synthetic growth hormone.	Stimulates natural GH release, but the levels achieved are significantly lower than with exogenous HGH. It is not equivalent.	Partially true

Studies and References (1)

Ipamorelin, a new growth-hormone-releasing peptide/compound

Raun K, Hansen BS, Johansen NL, et al. — European Journal of Endocrinology (1998) — n=12

Randomized Clinical Trial

Primeiro estudo detalhando a farmacologia do ipamorelin. Demonstrou liberação seletiva de GH sem afetar ACTH, cortisol, prolactina ou FSH/LH.

PubMed

Important notice

This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.

How to Obtain

This compound can be prepared by licensed compounding pharmacies with a valid prescription. Consult a physician first.

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