Melanotan II
Synthetic analog of alpha-MSH hormone that stimulates melanin production (tanning) and affects sexual function. Widely used in the underground market for sunless tanning. Not approved by any regulatory agency. Associated with significant risks.
Last updated:: 13/04/2026
Research Status
ANVISA (Brazil)
Not regulated
FDA (USA)
Not regulated
EMA (Europe)
Not regulated
Mechanism of Action
Melanotan II activates multiple melanocortin receptors (MC1R-MC5R). Via MC1R, it stimulates melanocytes to produce melanin, causing tanning without UV exposure. Via MC4R, it affects sexual desire centers in the hypothalamus (same receptor as PT-141/Vyleesi). Via MC3R/MC4R, it may suppress appetite.
Study Protocols
Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.
Bronzeamento / proteção UV
Subcutânea (SC)Iniciar com dose baixa para avaliar tolerância
Análogo da α-MSH. Induz melanogênese. Efeitos colaterais: náusea, rubor facial, aumento de libido. Não aprovado por agências reguladoras.
Benefits
Tanning without UV
ProvenPhase 2 clinical studies confirm significant increase in melanin and skin tanning without sun exposure.
Effect on sexual function
Under researchObserved side effect that led to the development of PT-141 (bremelanotide/Vyleesi) as a separate medication.
Risks and Side Effects
Atypical nevi / melanoma
High(Case reports)Reports of atypical nevi (irregular moles) appearing and potential malignant transformation. Melanocyte stimulation may promote melanoma in predisposed individuals.
Severe nausea
Moderate(Very common)Intense nausea is the most frequent side effect, especially with the first doses.
Increased blood pressure
Moderate(Common)Transient hypertension reported in clinical studies.
Product contamination
High(Variable)Products sold online are frequently contaminated or have incorrect dosing. No quality control.
Internet vs. Science
What people say online compared to the actual scientific evidence.
Safe tanning without sun
FalseWhat they claim
MT-2 gives a perfect tan without the risk of sunburn. Safer than sunbathing.
Actual evidence
Causes real tanning, but is NOT safe. Associated with atypical nevi and theoretical melanoma risk. Banned in Europe and Australia. Black market products are frequently contaminated. Not approved in any country.
| Claim | O que dizem | Evidência real | Verdict |
|---|---|---|---|
| Safe tanning without sun | MT-2 gives a perfect tan without the risk of sunburn. Safer than sunbathing. | Causes real tanning, but is NOT safe. Associated with atypical nevi and theoretical melanoma risk. Banned in Europe and Australia. Black market products are frequently contaminated. Not approved in any country. | False |
Frequently Asked Questions
Is Melanotan II legal?
No. Melanotan II is banned for consumer sale in most countries. The TGA (Australia) and MHRA (UK) have issued warnings against its use. ANVISA does not approve it. Products sold online operate illegally.
What is the difference between Melanotan II and PT-141?
PT-141 (bremelanotide/Vyleesi) was developed from Melanotan II, but modified to act predominantly on the MC4R receptor (sexual function) with less effect on MC1R (melanin). PT-141 is FDA-approved; Melanotan II is not approved in any country.
Important notice
This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.
How to Obtain
This compound can be prepared by licensed compounding pharmacies with a valid prescription. Consult a physician first.