Resveratrol
IMPORTANT: Resveratrol is not a peptide; it is a natural polyphenol found in red grapes, red wine, peanuts, and some fruits. It gained fame in the 2000s when mouse studies suggested it activated sirtuins (proteins associated with longevity). It is one of the most studied compounds in aging research.
Last updated:: 07/04/2026
Research Status
ANVISA (Brazil)
Not regulated
FDA (USA)
Not regulated
EMA (Europe)
Not regulated
Mechanism of Action
Resveratrol activates SIRT1, one of the sirtuins associated with longevity. It mimics some effects of caloric restriction. It has antioxidant, anti-inflammatory properties and improves mitochondrial function. It crosses the blood-brain barrier and reaches multiple tissues.
Study Protocols
Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.
Longevidade / cardioproteção
OralTrans-resveratrol, tomar com refeição gordurosa para absorção
Ativador de SIRT1. Mimetiza restrição calórica em obesos. Biodisponibilidade oral é baixa (~1–5%).
Benefits
Cardiovascular health
Under researchClinical studies show modest improvement in endothelial function, blood pressure, and inflammatory markers.
View studyInsulin sensitivity
Under researchMeta-analyses suggest modest improvement in glycemic control in patients with type 2 diabetes.
Anti-inflammatory
Under researchReduces systemic inflammatory markers in several clinical studies.
Human longevity
UnprovenMouse studies suggested increased longevity, but the effect was not replicated in other animal studies. No evidence of increased longevity in humans.
Risks and Side Effects
Very low bioavailability
Low(Universal)Resveratrol is rapidly metabolized and has very low oral bioavailability, raising questions about its efficacy at commercial doses.
Drug interactions
Moderate(Variable)May interact with anticoagulants and drugs metabolized by cytochrome P450.
Internet vs. Science
What people say online compared to the actual scientific evidence.
Drinking red wine gives you resveratrol benefits
FalseWhat they claim
Red wine is healthy because of resveratrol.
Actual evidence
The amount of resveratrol in red wine is so small that you would need to drink hundreds of bottles per day to reach studied doses. The possible cardiovascular benefits of red wine come from other compounds (and alcohol carries risks).
Sirtuin activator that reverses aging
Partially trueWhat they claim
Resveratrol activates sirtuins and reverses aging (popularized by David Sinclair).
Actual evidence
It activates SIRT1 in vitro. In humans, benefits are modest and the effect on longevity has never been demonstrated. Mouse studies were inconsistent.
| Claim | O que dizem | Evidência real | Verdict |
|---|---|---|---|
| Drinking red wine gives you resveratrol benefits | Red wine is healthy because of resveratrol. | The amount of resveratrol in red wine is so small that you would need to drink hundreds of bottles per day to reach studied doses. The possible cardiovascular benefits of red wine come from other compounds (and alcohol carries risks). | False |
| Sirtuin activator that reverses aging | Resveratrol activates sirtuins and reverses aging (popularized by David Sinclair). | It activates SIRT1 in vitro. In humans, benefits are modest and the effect on longevity has never been demonstrated. Mouse studies were inconsistent. | Partially true |
Studies and References (1)
Tomé-Carneiro J, Larrosa M, González-Sarrías A, et al. — Annual Review of Food Science and Technology (2013)
Revisão abrangente mostrando que enquanto resveratrol mostra benefícios consistentes em estudos animais, a tradução para humanos é limitada por baixa biodisponibilidade.
PubMedImportant notice
This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.
Where to Buy
This compound is available as a supplement. Purchase from trusted retailers:
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