Selank
Anxiolytic and nootropic peptide developed in Russia by the Institute of Molecular Genetics of the Russian Academy of Sciences. Approved in Russia as a medication for anxiety and neurasthenia. Synthetic analog of tuftsin, a natural immunomodulatory peptide.
Last updated:: 13/04/2026
Research Status
ANVISA (Brazil)
Not regulated
FDA (USA)
Compounding only
EMA (Europe)
Not regulated
Mechanism of Action
Selank is a heptapeptide analog of tuftsin with an added stabilizing sequence. It modulates GABAergic, serotonergic, and dopaminergic systems. It influences BDNF (brain-derived neurotrophic factor) expression and enkephalinase activity. It has an anxiolytic effect without sedation or dependence, unlike benzodiazepines.
Study Protocols
Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.
Ansiedade / função cognitiva
IntranasalSpray nasal, ciclos de uso
Análogo sintético da tuftsina. Aprovado na Rússia como ansiolítico. Modula IL-6, BDNF e monoaminas.
Benefits
Anxiolytic effect
ProvenApproved in Russia for anxiety treatment. Russian clinical studies demonstrated efficacy comparable to benzodiazepines without sedative effects.
Cognitive improvement
Under researchAnimal studies and some clinical trials suggest improvements in memory and concentration. Increases BDNF expression.
Immunomodulation
Under researchAs a tuftsin analog, it has documented immunomodulatory properties in preclinical studies.
Risks and Side Effects
Predominantly Russian studies
Moderate(N/A)Most clinical studies were conducted in Russia, with methodological limitations and publication in Russian journals. Internationally replicated studies are lacking.
Internet vs. Science
What people say online compared to the actual scientific evidence.
Replaces anxiolytics without side effects
Partially trueWhat they claim
Promoted as a natural alternative to benzodiazepines without risk of dependence.
Actual evidence
Approved in Russia as an anxiolytic without sedation, but studies were conducted under different standards than Western ones. The claim of zero side effects is exaggerated. Not approved by the FDA or EMA.
| Claim | O que dizem | Evidência real | Verdict |
|---|---|---|---|
| Replaces anxiolytics without side effects | Promoted as a natural alternative to benzodiazepines without risk of dependence. | Approved in Russia as an anxiolytic without sedation, but studies were conducted under different standards than Western ones. The claim of zero side effects is exaggerated. Not approved by the FDA or EMA. | Partially true |
Frequently Asked Questions
Is Selank approved in any country?
Yes, Selank is approved in Russia as a medication for generalized anxiety and neurasthenia, marketed as a nasal spray. It is not approved in the US, Europe, or Brazil.
Important notice
This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.
How to Obtain
This compound can be prepared by licensed compounding pharmacies with a valid prescription. Consult a physician first.