Sermorelin
GH-releasing hormone (GHRH) analog corresponding to the first 29 amino acids of natural GHRH. Was FDA-approved from 1997 to 2008 for GH deficiency in children. Now available through compounding pharmacies. One of the most studied GH secretagogues.
Last updated:: 06/04/2026
Research Status
ANVISA (Brazil)
Not regulated
FDA (USA)
Compounding only
EMA (Europe)
Not regulated
Mechanism of Action
Sermorelin binds to GHRH receptors in the anterior pituitary, stimulating the synthesis and pulsatile release of growth hormone. It preserves the natural negative feedback of the GH-IGF-1 axis, unlike exogenous GH which suppresses endogenous production.
Study Protocols
Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.
Deficiência de GH em adultos
Subcutânea (SC)Análogo do GHRH (1-29). Estimula secreção pulsátil fisiológica de GH. Mais seguro que GH exógeno para uso prolongado.
Benefits
Physiological GH increase
ProvenFDA-approved (1997-2008) for GH deficiency. Stimulates natural GH release while maintaining the physiological pulsatile pattern.
Improved body composition
ProvenClinical studies demonstrate increased lean mass and reduced body fat with prolonged use.
Improved sleep quality
Under researchClinical reports of improved deep sleep (slow-wave sleep), the phase during which GH is naturally released the most.
Risks and Side Effects
Injection site pain
Low(Common)Most reported side effect. Generally mild.
Facial flushing
Low(Uncommon)Transient flushing after injection.
Internet vs. Science
What people say online compared to the actual scientific evidence.
Better and safer than HGH
Partially trueWhat they claim
Sermorelin gives all the benefits of HGH without the risks.
Actual evidence
Stimulates natural GH (safer than exogenous GH which suppresses endogenous production), but the GH levels achieved are lower. It was FDA-approved, which gives it more credibility than many peptides. Commercially discontinued for market reasons, not safety concerns.
| Claim | O que dizem | Evidência real | Verdict |
|---|---|---|---|
| Better and safer than HGH | Sermorelin gives all the benefits of HGH without the risks. | Stimulates natural GH (safer than exogenous GH which suppresses endogenous production), but the GH levels achieved are lower. It was FDA-approved, which gives it more credibility than many peptides. Commercially discontinued for market reasons, not safety concerns. | Partially true |
Frequently Asked Questions
Why was Geref discontinued?
The manufacturer (Serono/EMD) voluntarily discontinued Geref in 2008 for commercial reasons (small market), not due to safety or efficacy problems. The peptide remains available through compounding pharmacies in the US.
Important notice
This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.
How to Obtain
This compound can be prepared by licensed compounding pharmacies with a valid prescription. Consult a physician first.