Qual a diferença entre TB-500 e Timosina Beta-4?

TB-500 é o nome comercial para uma versão sintética de um fragmento da timosina beta-4. A molécula não é idêntica à timosina beta-4 completa, embora compartilhe a região ativa responsável pelos efeitos biológicos.

RecuperaçãoTimosina Beta-4, Thymosin Beta-4

TB-500

Synthetic version of thymosin beta-4, a protein naturally present in nearly all cells in the human body. Researched for its effects on tissue healing, inflammation reduction, and cell regeneration. Popular among athletes, but with limited clinical evidence.

Last updated:: 06/04/2026

Research Status

Pré-clínicoFase 1Fase 2Fase 3Aprovado

ANVISA (Brazil)

Not regulated

FDA (USA)

Compounding only

EMA (Europe)

Not regulated

Mechanism of Action

Thymosin beta-4 is a 43-amino acid protein that regulates actin, an essential component of the cell cytoskeleton. It promotes cell migration, new blood vessel formation, and reduces inflammation. It also regulates the expression of genes involved in tissue repair.

Study Protocols

Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.

Recuperação de lesões e regeneração tecidual

Subcutânea (SC)

Fase de carga (semanas 1–4)2,0–2,5 mg2x/semana · 4 semanas

Manutenção (semanas 5–8)2,0 mg1x/semana · 4 semanas

Timosina beta-4. Evidência em modelos animais para cicatrização cardíaca e dérmica. Ensaios clínicos limitados em humanos.

Goldstein AL et al., Expert Opinion on Biological Therapy 2012

Benefits

Wound healing

Under research

Phase 2 clinical studies in skin ulcers showed promising results. RegeneRx Biopharmaceuticals conducted trials for dermal ulcers.

Cardiac regeneration

Under research

Preclinical studies demonstrated that TB-4 can activate cardiac progenitor cells and promote regeneration after myocardial infarction in animal models.

View study

Risks and Side Effects

Limited safety data

Moderate(Unknown)

Few completed human clinical studies. Long-term safety profile unknown.

Internet vs. Science

What people say online compared to the actual scientific evidence.

Recovers sports injuries in days

Inconclusive

What they claim

Athletes report dramatic recovery from muscle and tendon injuries.

Actual evidence

Animal evidence supports a healing effect, but there are no clinical studies confirming efficacy in sports injuries in humans. Anecdotal reports are not scientific evidence.

Claim	O que dizem	Evidência real	Verdict
Recovers sports injuries in days	Athletes report dramatic recovery from muscle and tendon injuries.	Animal evidence supports a healing effect, but there are no clinical studies confirming efficacy in sports injuries in humans. Anecdotal reports are not scientific evidence.	Inconclusive

Studies and References (1)

Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

Bock-Marquette I, Saxena A, White MD, et al. — Nature (2004)

Animal Study

Demonstrou que TB-4 promove sobrevivência de cardiomiócitos e regeneração cardíaca em camundongos após infarto do miocárdio.

PubMed

Frequently Asked Questions

What is the difference between TB-500 and Thymosin Beta-4?

TB-500 is the commercial name for a synthetic version of a fragment of thymosin beta-4. The molecule is not identical to the complete thymosin beta-4, although it shares the active region responsible for the biological effects.

Important notice

This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.

How to Obtain

This compound can be prepared by licensed compounding pharmacies with a valid prescription. Consult a physician first.

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