Urolitina A
IMPORTANT: Urolithin A is not a peptide; it is a metabolite produced by gut microbiota from ellagitannins found in pomegranate, raspberry, strawberry, and walnuts. Only 30-40% of people have the gut bacteria that naturally produce urolithin A — the rest need to supplement. The only compound clinically proven to induce mitophagy (mitochondrial recycling) in humans.
Last updated:: 07/04/2026
Research Status
ANVISA (Brazil)
Not regulated
FDA (USA)
Not regulated
EMA (Europe)
Not regulated
Mechanism of Action
Urolithin A induces mitophagy — the process of selectively recycling damaged mitochondria. Dysfunctional mitochondria accumulate with age, contributing to sarcopenia and metabolic decline. By removing these 'old' mitochondria, urolithin A improves the quality of the mitochondrial pool and cellular function.
Study Protocols
Dosages and regimens used in published clinical studies. This does not constitute a medical prescription.
Função mitocondrial / longevidade
OralMetabólito da elagitanina. Induz mitofagia. Melhora função muscular em idosos sedentários. Marca: Mitopure (Timeline Nutrition).
Benefits
Mitophagy induction in humans
ProvenThe only compound clinically demonstrated to induce mitophagy in humans. A study confirmed increased mitophagy markers in blood after 28 days.
View studyMuscle function
Under researchClinical studies demonstrated improvement in muscle strength and endurance in middle-aged and elderly adults.
View studyMitochondrial health
Under researchImproves markers of mitochondrial function and biogenesis in clinical studies.
Risks and Side Effects
Favorable safety profile
Low(Rare)Clinical studies show an excellent safety profile. Adverse events are rare and mild (gastrointestinal).
High cost
Low(N/A)Mitopure (the only clinically studied form) has significant cost, equivalent to $60-90/month.
Internet vs. Science
What people say online compared to the actual scientific evidence.
Muscle longevity pill
Partially trueWhat they claim
Urolithin A gives you young muscles without working out.
Actual evidence
Improves mitochondrial function and muscle markers, but does not replace exercise. Benefits are modest (approximately 12% improvement in muscle endurance). Not magic.
| Claim | O que dizem | Evidência real | Verdict |
|---|---|---|---|
| Muscle longevity pill | Urolithin A gives you young muscles without working out. | Improves mitochondrial function and muscle markers, but does not replace exercise. Benefits are modest (approximately 12% improvement in muscle endurance). Not magic. | Partially true |
Studies and References (2)
Liu S, D'Amico D, Shankland E, et al. — JAMA Network Open (2022) — n=88
Suplementação com 1g/dia de urolitina A por 4 meses melhorou força muscular dos extensores de joelho e ATP mitocondrial em adultos de meia-idade.
PubMedRyu D, Mouchiroud L, Andreux PA, et al. — Nature Medicine (2016)
Estudo pioneiro: urolitina A induziu mitofagia e prolongou vida em C. elegans, e melhorou função muscular em camundongos jovens e idosos.
PubMedFrequently Asked Questions
Can I obtain urolithin A naturally?
Only 30-40% of people have the gut microbiota capable of converting ellagitannins (from pomegranate, walnuts, raspberries) into urolithin A. For the other 60-70%, direct supplementation is the only way to obtain it. A urine test can determine whether you are a natural producer.
Important notice
This content is strictly informational and educational, based on published scientific research. It does not constitute medical advice, prescription, or encouragement to use any substance. Always consult a qualified physician before starting any treatment.
Where to Buy
This compound is available as a supplement. Purchase from trusted retailers:
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